| Synthesis of 5-Substituted-3-[(2’R,4’R)-4’-Hydroxy-2’-hydroxymethyltetrahydrofuran-4’-yl]-1,2,4-oxadiazoles and Their Epimers |
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| 引用本文： | WU Wei-dong,MA Ling-tai and ZHANG Li-he* *(National Laboratory of Natural and Biomimetic Drugs,School ofPharmaceutical Sciences,Peking University,Beijing 100083) P. R. China). Synthesis of 5-Substituted-3-[(2’R,4’R)-4’-Hydroxy-2’-hydroxymethyltetrahydrofuran-4’-yl]-1,2,4-oxadiazoles and Their Epimers[J]. 高等学校化学研究, 2001, 0(4) |
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| 作者姓名： | WU Wei-dong MA Ling-tai and ZHANG Li-he* *(National Laboratory of Natural and Biomimetic Drugs School ofPharmaceutical Sciences Peking University Beijing 100083) P. R. China) |
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| 作者单位： | National Laboratory of Natural and Biomimetic Drugs，School ofPharmaceutical Sciences，Peking University，Beijing 100083) P. R. China) |
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| 基金项目： | National Natural Science Foundation of China． |
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| 摘 要： | The syntheses of 5-substituted-3-[( 2' R, 4' R)-4 ' -hydroxy-2 ' -hydroxymethyltetra-hydrofuran-4' -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization.
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Synthesis of 5-Substituted-3-[(2' R,4' R)-4' -Hydroxy-2/ -hydroxymethyltetrahydrofuran-4/ -yl]-1,2,4-oxadiazoles and Their Epimers |
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| WU Wei-dong,MA Ling-tai and ZHANG Li-he. Synthesis of 5-Substituted-3-[(2' R,4' R)-4' -Hydroxy-2/ -hydroxymethyltetrahydrofuran-4/ -yl]-1,2,4-oxadiazoles and Their Epimers[J]. Chemical Research in Chinese University, 2001, 0(4) |
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| Authors: | WU Wei-dong MA Ling-tai ZHANG Li-he |
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| Affiliation: | WU Wei-dong,MA Ling-tai and ZHANG Li-he* * |
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| Abstract: | The syntheses of 5-substituted-3-[( 2' R, 4' R)-4 ' -hydroxy-2 ' -hydroxymethyltetra-hydrofuran-4' -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization. |
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| Keywords: | Keywords Nucleoside analogue 1 2 4-Oxadiazole Transacylation |
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