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| Graft Polymerization of Acryloyloxystarch with Poly (D, L-lactide) Macromonomer——A Potential Drug Delivery Carrier for Oral Administration | |
| 作者姓名： | WANG Li-qun~ |
| 作者单位： | WANG Li-qun~(1，3**)，TU Ke-hua~1，WANG Yan-bing~1 and LI Xiang-rong~2(1. Department of Polymer Science and Engineering; 2. College of Medicine of Zhejiang University，Hangzhuo 310027，P. R. China; 3. Key Laboratory of Molecular Engineering of Polymers，Fudan University，Shanghai 200433，P. R. China) To whom correspondence should be addressed. |
| 基金项目： | Supported by the Natural Science Foundation of China, the Natural Science Foundation of Zhejiang Province and the Visiting Scholarship of the Key Laboratory of Molecular Engineering of Polymers at Fudan University, the Ministry of Education of China. |
| 摘 要： | Starch is the second largest natural biopolymer. Its unique biodegradable and biocompatible properties make it be increasingly applied to the field of biomedicine. As one kind of polysaccharide, starch is easily degraded into small organic molecules by amylase in the alimentary canal. The fact that the activity of amylase is restrained in the high acid environment in stomach provides an opportunity to prepare an intestinal-specific delivery carrier with |
| 收稿时间： | 2001-04-17 |
Graft Polymerization of Acryloyloxystarch with Poly(D,L-lactide) Macromonomer--A Potential Drug Delivery Carrier for Oral Administration |
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| WANG Li-qun.Graft Polymerization of Acryloyloxystarch with Poly(D,L-lactide) Macromonomer--A Potential Drug Delivery Carrier for Oral Administration[J].Chemical Research in Chinese University,2001,17(3):334-337. | |
| Authors: | WANG Li-qun TU Ke-hua WANG Yan-bing LI Xiang-rong |
| Institution: | 1. Department of Polymer Science and Engineering; 2. College of Medicine of Zhejiang University, Hangzhuo 310027, P. R. China; 3. Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, P. R. China; |
| Abstract: | Starch is the second largest natural biopolymer. Its unique biodegradable and biocompatible properties make it be increasingly applied to the field of biomedicine. As one kind of polysaccharide, starch is easily degraded into small organic molecules by amylase in the alimentary canal. The fact that the activity of amylase is restrained in the high acid |
| Keywords: | Acryloyloxystarch PLA macromonomer Graft copolymerization |
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