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Characterization and synthesis of a new calcium antagonist from the venom of a fishing spider |
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| Authors: | Kevin D. McCormick Kazumi Kobayashi Stanley M. Goldin N. Laxma Reddy Jerrold Meinwald |
| Affiliation: | a Cornell Institute for Research in Chemical Ecology (CIRCE) Department of Chemistry Cornell University Ithaca, New York 14853-1301 U.S.A. b Cambridge NeuroScience One Kendall Square, Building 700 Cambridge, Massachusetts 02139 U.S.A. |
| Abstract: | A new calcium antagonist, CNS 2103, is isolated from the venom of a fishing spider, Dolomedes okefinokensis. The structure of this compound is derived from spectroscopic data, including tandem mass spectrometry. A flexible, convergent synthesis of CNS 2103 is described. |
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