Effect of Gd-EOB-DTPA on hepatic fat quantification using high-speed T2-corrected multi-echo acquisition in H MR spectroscopy |
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Authors: | Yang Shin Park Chang Hee Lee Ji Hoon Kim Baek Hui Kim Jeoung Hyun Kim Kyeong Ah Kim Cheol Min Park |
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Institution: | 1. Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea;2. Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea;3. Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea;4. Department of Radiology, Ewha Womans University Mokdong Hospital, Seoul, Korea |
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Abstract: | PurposeTo determine whether gadolinium ethoxybenzyldiethylenetriaminepentaacetic acid (Gd-EOB-DTPA) administration affects hepatic fat quantification by magnetic resonance spectroscopy (MRS) using the fast breath-hold high-speed T2-corrected multiecho (HISTO) technique.Materials and MethodsSeventy-six patients underwent Gd-EOB-DTPA-enhanced liver MR and 15 sec breath-hold HISTO MRS (4 times), twice before and twice after Gd-EOB-DTPA administration. Two consecutive MRSs were performed immediately before the dynamic study. Post-contrast MRS was performed twice continuously, approximately 15 min after contrast injection, prior to obtaining 20-min hepatobiliary phase images. We used paired t-test and intraclass correlation coefficient (ICC) to evaluate the variability of the mean fat fraction (FF) on pre-contrast MRS and post-contrast MRS and the effect of the contrast agent on the mean FF.ResultsThe mean FFs were not significantly different between pre-contrast MRS and post-contrast MRS (6.50% ± 6.54 versus 6.70% ± 6.61, P = 0.15). The ICC of FF calculation between pre- and post-contrast MRS was 0.984. The ICCs for the FF magnitude between pre- and post-contrast MRS were 0.452, 0.771, and 0.995 for FF < 5%, FF 5–10%, and FF ≥ 10%, respectively.ConclusionGd-EOB-DTPA does not appear to influence hepatic fat quantification, especially for patients with hepatic steatosis. |
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Keywords: | Fatty liver MRI MR spectroscopy High-speed T2-corrected multi-echo Liver |
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