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Proton density water fraction as a biomarker of bone marrow cellularity: Validation in ex vivo spine specimens |
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| Authors: | Iain J MacEwan Nicholas E Glembotski Darryl D’Lima Won Bae Koichi Masuda Hooman H Rashidi Loren K Mell Mark Bydder |
| Institution: | 1. Center for Advanced Radiotherapy Technologies, Department of Radiation Medicine and Applied Sciences, 3855 Health Sciences Dr. #0843, La Jolla, CA, USA;2. Scripps Translational Science Institute, 3344 North Torrey Pines Court Suite 300, La Jolla, CA, USA;3. Department of Radiology, University of California San Diego, 408 Dickinson Street, San Diego, CA, USA;4. Skeletal Translational Research Laboratory, Department of Orthopaedic Surgery, School of Medicine, University of California, San Diego, CA, USA;5. Department of Pathology, University of California San Diego, School of Medicine & VA Medical Center, San Diego, CA, USA |
| Abstract: | The purpose of this study was to evaluate a magnetic resonance imaging (MRI) technique for quantifying the proton density water fraction (PDWF) as a biomarker of bone marrow cellularity. Thirty-six human bone marrow specimens from 18 donors were excised and subjected to different measurements of tissue composition: PDWF quantification using a multiple gradient echo MRI technique, three biochemical assays (triglyceride, total lipid and water content) and a histological assessment of cellularity. Results showed a strong correlation between PDWF and bone marrow cellularity from histology (r = 0.72). A strong correlation was also found between PDWF and the biochemical assay of water content (r = 0.76). These results suggest the PDWF is a predictor of bone marrow cellularity in tissues and can provide a non-invasive assessment of bone marrow changes in clinical patients undergoing radiotherapy. |
| Keywords: | Bone marrow Cellularity MRI Fat quantification |
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