Effects of RF profile on precision of quantitative T2 mapping using dual-echo steady-state acquisition |
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| Authors: | Pei-Hsin Wu Cheng-Chieh Cheng Ming-Long Wu Tzu-Cheng Chao Hsiao-Wen Chung Teng-Yi Huang |
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| Institution: | 1. Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan;2. Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan;3. Institute of Medical Informatics, National Cheng-Kung University, Tainan, Taiwan;4. Department of Computer Science and Information Engineering, National Cheng-Kung University, Tainan, Taiwan;5. Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan |
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| Abstract: | The dual echo steady-state (DESS) sequence has been shown successful in achieving fast T2 mapping with good precision. Under-estimation of T2, however, becomes increasingly prominent as the flip angle decreases. In 3D DESS imaging, therefore, the derived T2 values would become a function of the slice location in the presence of non-ideal slice profile of the excitation RF pulse. Furthermore, the pattern of slice-dependent variation in T2 estimates is dependent on the RF pulse waveform. Multi-slice 2D DESS imaging provides better inter-slice consistency, but the signal intensity is subject to integrated effects of within-slice distribution of the actual flip angle. Consequently, T2 measured using 2D DESS is prone to inaccuracy even at the designated flip angle of 90°. In this study, both phantom and human experiments demonstrate the above phenomena in good agreement with model prediction. |
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| Keywords: | Dual-echo steady-state imaging T2 quantification Flip angle dependency Slice profile 2D and 3D imaging |
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