Transfer characteristics of arterial pulsatile force in regional intracranial tissue using dynamic diffusion MRI: A phantom study |
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Authors: | Hirohito Kan Tosiaki Miyati Harumasa Kasai Nobuyuki Arai Naoki Ohno Mitsuhito Mase Yuta Shibamoto |
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Affiliation: | 1. Department of Radiology, Nagoya City University Hospital, 1-Kawasumi, Mizuho-cho Mizuho-ku, Nagoya City, Aichi, 4678602, Japan;2. Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, 9200942, Japan;3. Department of Neurosurgery, Nagoya City University Hospital, 1-Kawasumi, Mizuho-cho Mizuho-ku, Nagoya City, Aichi, 4678602, Japan |
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Abstract: | IntroductionTo clarify the mechanism underlying apparent diffusion coefficient (ADC) changes in regional intracranial tissue during the cardiac cycle, we investigated relationships among ADC changes, volume loading, and intracranial pressure using a hemodialyzer phantom in magnetic resonance imaging (MRI).Materials and MethodsThe hemodialyzer phantom consisted of hollow fibers (HF), the external space of HFs (ES), and a gateway of dialysis solution, filled with syrup solution and air. The high-volume and low-volume loadings were periodically applied to HFs by a to-and-fro flow pump, and syrup solution was permitted to enter or leave HFs during the volume loading cycles. ADC maps at each volume loading phase were obtained using ECG-triggered single-shot diffusion echo-planar imaging. Dynamic phase contrast MRI was also used to measure volume loading to the phantom. We compared the ADC changes, volume loading, and intracranial pressure in the phantom during the cardiac cycle.ResultsADC changes synchronized significantly with absolute volumetric flow rate change. The maximum ADC change was higher in high-volume loading cycles than in low-volume loading cycles. Results showed that the water molecules in ES fluctuated according to the force transferred from HF to ES. ADC changes were dependent upon the volumetric flow rate during the cardiac cycle.ConclusionsOur original phantom allowed us to clarify the mechanism underlying water fluctuations in intracranial tissues. Measurement of maximum changes in ADC is an effective method to define the transfer characteristics of the arterial pulsatile force in regional intracranial tissue. |
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Keywords: | Magnetic resonance imaging Diffusion weighted imaging Apparent diffusion coefficient Water molecular fluctuation |
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