Using intravoxel incoherent motion (IVIM) MR imaging to predict lipiodol uptake in patients with hepatocellular carcinoma following transcatheter arterial chemoembolization: A preliminary result |
| |
Authors: | Yang Shin Park Chang Hee Lee Ji Hoon Kim In Seong Kim Berthold Kiefer Tae Seok Seo Kyeong Ah Kim Cheol Min Park |
| |
Institution: | 1. Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea;2. Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea;3. Siemens Healthcare, Seoul, Korea;4. Siemens Healthcare, Oncology Application Development, Erlangen, Germany |
| |
Abstract: | PurposeTo assess the usefulness of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) for predicting lipiodol uptake in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE).Materials and methodsThe institutional review board approved this study. 44 HCC patients underwent IVIM-DWI and Gd-EOB-DTPA-enhanced MRI prior to TACE. Using post-TACE CT as a reference standard, each HCC was classified into either lipiodol good uptake (LGU) or poor uptake (LPU) group. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), perfusion coefficient (D*), and perfusion fraction (f) in HCC were calculated. Arterial enhancement ratio (AER) and IVIM parameters were compared between those two groups using the Mann-Whitney U test.ResultsOf the 51 HCCs, 37 (72.5%) were LGU group and 14 (27.5%) were LPU group. AER of HCC was significantly higher in LGU than LPU (0.99 ± 0.54 and 0.67 ± 0.45; P = .034). ADC, D, and f values were not significantly different (P = .073, .059, and .196, respectively) between these two groups. D* was significantly elevated in LGU than LPU (48.10 ± 15.33 and 26.75 ± 9.55; P = .001).ConclusionBoth AER derived from contrast enhanced MRI and D* values derived from IVIM-DWI for HCC were significantly higher in LGU than in LPU. These parameters would be helpful for predicting the lipiodol uptake. |
| |
Keywords: | Liver MRI IVIM DWI TACE Hepatocellular carcinoma |
本文献已被 ScienceDirect 等数据库收录! |
|