Halichonadins G-J, new sesquiterpenoids from a sponge Halichondria sp. |
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Authors: | Shohei SutoNaonobu Tanaka Jane FromontJun’ichi Kobayashi |
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Institution: | a Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan b Western Australian Museum, Locked Bag 49, Weishpool DC, WA 6986, Australia |
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Abstract: | Three new dimeric sesquiterpenoids, halichonadins G-I (1-3), and one new eudesmane sesquiterpenoid possessing a 1-phenethyl urea moiety, halichonadin J (4), were isolated from a marine sponge Halichondria sp. Halichonadins G (1) and H (2) are homo-dimers of eudesmane sesquiterpenoid, linked through a methyl 2-{1-(2-amino-2-oxoethyl)ureido}acetate fragment and a 2-hydroxymalonamide fragment, respectively, while halichonadin I (3) is a new hetero-dimer of eudesmane sesquiterpenoid linked through a urea fragment. The structures of 1-4 were elucidated on the basis of spectroscopic data. |
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Keywords: | Marine sponge Halichondria sp Sesquiterpenoids Halichonadins G-J |
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