| IMPROVING NONTHROMBOGENICITY OF CHITIN WITH ZWITTERIONIC STRUCTURE OF SULFOBETAINE |
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| 引用本文： | JunZhua Chang-wangPan LingTong HanYan JianShen Si-congLin. IMPROVING NONTHROMBOGENICITY OF CHITIN WITH ZWITTERIONIC STRUCTURE OF SULFOBETAINE[J]. 高分子科学, 2005, 0(4): 449-452 |
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| 作者姓名： | JunZhua Chang-wangPan LingTong HanYan JianShen Si-congLin |
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| 作者单位： | [1]ResearchCenterofSurface＆InterfaceChemistryandEngineeringTechnology,NanjingUniversity,Nanjing210093,China [2]ResearchCenterofSurface＆InterfaceChemistryandEngineeringTechnology,NanjingUniversity,Nanjing210093,China／／CollegeofChemistry＆EnvironmentScience,NanjingNormalUniversity,Nanjing210097,China |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | In order to improve the nonthr0mbogenicity of chitin, a new monomer, N, N-dimethyl(β-hydroxyethyloxyethyl) ammonium propanesulfonate (DHAPS) was designed, synthesized and grafted onto the chitin membrane by using hexamethylene diisocyanate (HDI) as a coupling agent. Surface analysis of the grafted membranes by ATR-FTIR and XPS confirms that DHAPS has been successfully grafted onto the membrane surface. The platelet resistant property of the grafted membranes was evaluated by a platelet-rich plasma adhesion method. The results showed that platelet-adhesive resistance of the modified membrane has been greatly improved.
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| 关 键 词： | 几丁质 两性离子生物材料 表面修饰 血小板附着 血栓 磺基三甲铵乙内酯 |
| 收稿时间： | 2004-08-05 |
| 修稿时间： | 2005-01-05 |
Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine |
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| Jun Zhu,Chang-wang Pan,Ling Tong,Han Yan,Jian Shen,Si-cong Lin. Improving Nonthrombogenicity of Chitin with Zwitterionic Structure of Sulfobetaine[J]. Chinese Journal of Polymer Science, 2005, 0(4): 449-452 |
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| Authors: | Jun Zhu Chang-wang Pan Ling Tong Han Yan Jian Shen Si-cong Lin |
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| Affiliation: | Research Center of Surface & Interface Chemistry and Engineering Technology, |
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| Abstract: | In order to improve the nonthrombogenicity of chitin, a new monomer, N, N-dimethyl(β-hydroxyethyloxyethyl)ammonium propanesulfonate (DHAPS) was designed, synthesized and grafted onto the chitin membrane by using hexamethylene diisocyanate (HDI) as a coupling agent. Surface analysis of the grafted membranes by ATR-FTIR and XPS confirms that DHAPS has been successfully grafted onto the membrane surface. The platelet resistant property of the grafted membranes was evaluated by a platelet-rich plasma adhesion method. The results showed that platelet-adhesive resistance of the modified membrane has been greatly improved. |
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| Keywords: | Chitin Nonthrombogenic chitin Zwitterionic biomaterials Surface modification Platelet adhesion |
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