One-pot preparation of chiral beta-amino esters by rhodium-catalyzed three-components coupling reaction |
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| Authors: | Honda Toshio Wakabayashi Hitoshi Kanai Kazuo |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. honda@hoshi.ac.jp |
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| Abstract: | Chiral beta-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatsky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imines prepared in |
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