Supercritical fluid extraction of Kava lactones from Kava root and their separation via supercritical fluid chromatography |
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Authors: | M. Ashraf-Khorassani L. T. Taylor M. Martin |
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Affiliation: | (1) Department of Chemistry, Virginia Tech, 24061-0202 Blacksburg, VA, USA;(2) Armadillo Pharmaceutical, P.O. Box 333 Hakalau, HI 96710, USA |
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Abstract: | Summary Seven Kava lactones were extracted from Kava root using both pure and 15% ethanol modified CO2. Most of the Kava lactones were extracted employing 100% CO2 with an efficiency greater than 90% relative to conventional solvent extraction using organic solvents. Extraction efficiency did not increase significantly when using 15% ethanol-modified CO2 as an extraction fluid. Separation of extracted Kava lactones was obtained using various packed columns and methanol-modified CO2. An optimized separation was achieved using either an amino or protein C4 column at 125 atm and 80°C. Semi-preparative separation of Kava lactones was also obtained using two columns connected in series. |
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Keywords: | Supercritical fluid extraction Supercritical fluid chromatography Kava root lactones |
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