Pd-catalyzed silicon hydride reductions of aromatic and aliphatic nitro groups |
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Authors: | Rahaim Ronald J Maleczka Robert E |
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Institution: | Department of Chemistry, Michigan State University, East Lansing, 48824, USA. |
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Abstract: | reaction: see text] Room-temperature reduction of aromatic nitro groups to amines can be accomplished in high yield, with wide functional group tolerance and short reaction times (30 min) using a combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS). Replacing PMHS/KF with triethylsilane allows aliphatic nitro groups to be reduced to their hydroxylamines. |
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