In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi |
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Authors: | Lopes Adriana Aparecida López Silvia Noelí Regasini Luis Octávio Junior João Marcos Batista Ambrósio Daniela Luz Kato Massuo Jorge da Silva Bolzani Vanderlan Cicarelli Regina Maria Barretto Furlan Maysa |
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Affiliation: | Instituto de Quimica, Universidade Estadual Paulista, Araraquara, SP, Brazil. |
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Abstract: | This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 microg mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 microg mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives. |
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