| Dendrimer PAMAM为手臂的LDL吸附剂制备及性能研究 |
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| 引用本文： | 袁毅,王燕铭,俞耀庭.Dendrimer PAMAM为手臂的LDL吸附剂制备及性能研究[J].离子交换与吸附,2008,24(1):1-9. |
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| 作者姓名： | 袁毅 王燕铭 俞耀庭 |
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| 作者单位： | 1. 南开大学生物活性材料教育部重点实验室,天津,300071;天津大学化工学院生物工程系,天津,300072
2. 南开大学生物活性材料教育部重点实验室,天津,300071 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，中国博士后科学基金 |
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| 摘 要： | 树状高分子聚酰胺-胺(Dendrimer PAMAM)是一种具有大量活泼氨基末端的对称大分子.通过官能团转化,可将其变为具有不同端基的新性能的树状高分子.本文研究了不同代数的Dendrimer PAMAM作为血液净化吸附剂的"手臂"对配基牛磺酸的连接和对LDL吸附性能的影响.初步研究树状高分子的手臂效应,证明使用枝化手臂是一种能提高吸附剂吸附性能的有效方法.
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| 关 键 词： | 低密度脂蛋白吸附剂 手臂 树状高分子聚酰胺-胺 |
| 文章编号： | 1001-5493(2008)01-0000-09 |
| 收稿时间： | 2007-04-25 |
| 修稿时间： | 2007年4月25日 |
STUDY OF THE LDL ADSORBENT WITH DENDRIMER PAMAM AS THE SPACER |
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| YUAN Yi,WANG Yanming,YU Yaoting.STUDY OF THE LDL ADSORBENT WITH DENDRIMER PAMAM AS THE SPACER[J].Ion Exchange and Adsorption,2008,24(1):1-9. |
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| Authors: | YUAN Yi WANG Yanming YU Yaoting |
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| Abstract: | Dendritic polymers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences. The syntheses proceed via discrete stages referred to as generations. To study the spacer effect of LDL adsorbent, we linked dendrimer PAMAM generation 1 (G1), generation 3 (G3), generation 5 (G5) to cellulose beads respectively, and then determined the adsorption proportion of the adsorbents with taurine decorated PAMAM. The result showed that the spacer with multi-activated points could improve the adsorption capacity of the adsorbent. Moreover, the molecular weight and size of G3 were the most suitable for the adsorption of LDL. |
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| Keywords: | LDL adsorbent Spacer Dendrimer PAMAM |
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