Concise synthesis of the oxapentacyclic core of cortistatin A |
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| Authors: | Yu Fangmiao Li Guozhi Gao Peng Gong Hongju Liu Yinghua Wu Yongming Cheng Bin Zhai Hongbin |
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| Institution: | The Key Laboratory of Synthetic Chemistry of Natural Substances and the State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China. |
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| Abstract: | A concise synthetic approach for constructing the oxapentacyclic framework of cortistatin A is described. The synthesis features a furan-oxyallyl 4 + 3] cycloaddition and double-intramolecular aldol reactions. In addition, an interesting core structure was obtained in 11 steps from furan by using our method. |
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