Pd-catalyzed domino carbonylative-decarboxylative allylation: an easy and selective monoallylation of ketones |
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Authors: | Giboulot Steven Liron Frédéric Prestat Guillaume Wahl Benoit Sauthier Mathieu Castanet Yves Mortreux André Poli Giovanni |
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Institution: | UPMC, IPCM, UMR CNRS 7201, 4 place Jussieu, case 183, F-75252 Paris Cedex 05, France. |
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Abstract: | In the presence of an allyl alcohol, α-chloroacetophenones undergo an allyloxycarbonylation reaction followed by in situ decarboxylative allylation to selectively afford the corresponding monoallylated ketones via a Pd-catalyzed domino sequence. The scope of the reaction was extended to substituted α-chloroacetophenones as well as various allyl alcohols. |
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