Synthesis of L-kedarosamine in protected form and its efficient incorporation into an advanced intermediate to kedarcidin chromophore |
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Authors: | Ren Feng Hogan Philip C Anderson Alan J Myers Andrew G |
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Institution: | Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. |
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Abstract: | An efficient route to the complex L-kedarosamine alpha-glycosidic ether 2, a synthetic precursor to kedarcidin chromophore, is described. Central to the route, which is suitable for the preparation of multigram amounts of material, is a short synthetic sequence from D-threonine to protected L-kedarosamine derivatives and methodology for their alpha-selective coupling with appropriate hydroxyl acceptors. |
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