Ribosylation of adenosine: an orthogonally protected building block for the synthesis of ADP-ribosyl oligomers |
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| Authors: | van der Heden van Noort Gerbrand J Overkleeft Herman S van der Marel Gijsbert A Filippov Dmitri V |
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| Affiliation: | Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands. |
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| Abstract: | A method to ribosylate adenosine on the 2' hydroxyl function in an α-selective fashion and in good yield is presented. Protective groups chosen for the acceptor and donor used in this glycosylation not only direct α-selectivity but also allow the construction of a fully orthogonally protected building block for the future assembly of oligo-ADP-ribosylated peptides and proteins. |
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