| Construction of the Skeleton of Phthalascidin, Mechanism of the Formation of the Key Tricyclic Lactam Intermediate |
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| 引用本文： | Zhan Zhu LIU,Ye WANG,Shi Zhi CHEN* Institute of Materia Medica,Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing 100050. Construction of the Skeleton of Phthalascidin, Mechanism of the Formation of the Key Tricyclic Lactam Intermediate[J]. 中国化学快报, 2002, 13(8) |
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| 作者姓名： | Zhan Zhu LIU Ye WANG Shi Zhi CHEN* Institute of Materia Medica Chinese Academy of Medical Sciences& Peking Union Medical College Beijing 100050 |
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| 作者单位： | Zhan Zhu LIU，Ye WANG，Shi Zhi CHEN* Institute of Materia Medica，Chinese Academy of Medical Sciences& Peking Union Medical College，Beijing 100050 |
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| 摘 要： | Phthalascidin is a structurally simplified version of Et-743, which is a potent anti-tumor marine natural product isolated from Ecteinascidia turbinata. Its antiproliferative activity is greater than that of the agents taxol, camptothecin, adriamycin, mitomycin C, cisplatin, bleomycin, and etoposide by 1-3 orders of magnitude. An elegant synthesis of Et-743 and phthalascidin has been reported by E. J. Corey and co-workers1,2. As part of our continuing program, we have also engaged in dev…
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Construction of the Skeleton of Phthalascidin, Mechanism of the Formation of the Key Tricyclic Lactam Intermediate |
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| Zhan Zhu LIU,Ye Wang,Shi Zhi CHEN. Construction of the Skeleton of Phthalascidin, Mechanism of the Formation of the Key Tricyclic Lactam Intermediate[J]. Chinese Chemical Letters, 2002, 13(8) |
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| Authors: | Zhan Zhu LIU Ye Wang Shi Zhi CHEN |
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| Abstract: | The mechanism of the formation of a key tricyclic lactam intermediate 3 was studied. It was found that the E-form compound 3 was transformed from the Z-form compound 4. The formation of 4 was a kinetically controlled process while the formation of 3 was a thermodynamically favorable one. A possible mechanism was given in this paper. |
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| Keywords: | Lactam phthalascidin mechanism Et-743. |
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