| 富锌排铅咀嚼片安全性毒理学评价 |
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| 引用本文： | 冯福建,王五一,虞江萍,扬林生,李永华. 富锌排铅咀嚼片安全性毒理学评价[J]. 广东微量元素科学, 2006, 13(11): 27-34 |
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| 作者姓名： | 冯福建 王五一 虞江萍 扬林生 李永华 |
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| 作者单位： | 中国科学院地理科学与资源研究所,北京,100101 |
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| 基金项目： | 中国科学院知识创新工程重要方向性项目(课题号KZCX3-SW-437)，国家自然科学基金项目(40571008) |
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| 摘 要： | 对富锌排铅咀嚼片(RZLR)进行了急性毒性试验、Ames试验、骨髓微核试验、精子畸形试验和30 d喂养试验。结果表明,小鼠急性毒性LD50(BW)>21 500 mg/kg,属无毒级;Ames试验、小鼠骨髓微核试验、精子畸形试验和30 d喂养试验结果均为阴性;30 d喂养试验也未显示明显毒性。本研究证实RZLR是一种安全、无毒副作用的保健食品。
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| 关 键 词： | 毒理学评价 保健食品 富锌排铅咀嚼片 |
| 文章编号： | 1006-446X（2006）11-0027-08 |
| 收稿时间： | 2006-07-31 |
| 修稿时间： | 2006-07-31 |
Toxicological Evaluation on Safety of Rich Zinc Lead-Removing Tablet |
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| FENG Fujian,WANG Wuyi,YU Jiangping,YANG Linsheng,LI Yonghua. Toxicological Evaluation on Safety of Rich Zinc Lead-Removing Tablet[J]. Trace Elements Science, 2006, 13(11): 27-34 |
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| Authors: | FENG Fujian WANG Wuyi YU Jiangping YANG Linsheng LI Yonghua |
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| Abstract: | Acute toxicity test,Ames test,cell micronucleus test,sperm shape abnormality test,and thirty days feeding test for rich zinc lead-removing tablet(RZLR)been had studied.The results showed that the oral LD_(50)(BW)in mice was greater than 21 500 mg/kg and belonged to the nonpoisonous.The negative results were obtained all for cell micronucleus test,sperm shape abnormality test,Ames test and thirty days feeding test,and significant toxicology of RZLR was not observed in thirty days feeding tests.The study had proved that RZLR was a health food of safety. |
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| Keywords: | zinc lead-removing tablet health food toxicology evaluation |
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