The transformations of 4-heteroarylaminomethylene-5(4H)-oxazolones into dehydropeptide derivatives |
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Authors: | Mateja Alja-Roi Jurij Svete Branko Stanovnik |
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Institution: | Mateja Aljaẑ-Roẑiĉ,Jurij Svete,Branko Stanovnik |
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Abstract: | 2-Phenyl-4-heteroarylaminomethylene-5(4H)-oxazolones 3 , which were prepared from the corresponding N,N-dimethyl-N'-heteroarylformamidines 1 and hippuric acid 2 in acetic anhydride, react with amino acids giving dehydropeptide derivatives 4, 5 , and 6 as products. Dehydration of N-protected peptides 7–10 , containing glycine at the C-terminal, followed by the reaction with formamidines 1 gave 2-substituted-4-heteroarylaminomethylene-5(4H)-oxazolones 11–14 . |
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