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A Practical Route to Chiral Phenylalanine via the Condensation of Keto Acids with Amides and Asymmetric Hydrogenation |
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| Authors: | Tay-Yuan Chau Jian-Hou Tsui Chi-Ching Lin A. S. C. Chan |
| Abstract: | The condensation of β-phenylpyruvic acid with amides gave olefinic intermediates in good yields (75-80%). The asymmetric catalytic hydrogenation of α-acetamidocinnamic acid with high enantioselectivity is described. |
| Keywords: | Chiral amino acids Asymmetric hydrogenation β -Phenylpyuvic acid α -Acetamidocinnamic acid S-Phenylalanine |