| 反相高效液相色谱法测定新药阿司匹林铜 |
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| 引用本文： | 刘祝东,刘伟平,杨懿昆,普绍平,谌喜珠,何键,熊惠周.反相高效液相色谱法测定新药阿司匹林铜[J].分析化学,1999,27(10):1160-1163. |
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| 作者姓名： | 刘祝东 刘伟平 杨懿昆 普绍平 谌喜珠 何键 熊惠周 |
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| 作者单位： | 昆明贵金属研究所,昆明,650221 |
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| 摘 要： | 提出测定阿司匹林铜新药的反相高效液相色谱分析方法，采用国产ＹＷＱ Ｃ１８柱，在２５℃下，甲醇：水（含０．０８％正磷酸）：丙酮＝１１．４：８．６：１．１为流动相，苯甲酸为内标，药用标准阿司匹林和水杨酸为对照品，在ＵＶ－２３５ｎｍ下检测阿司匹林铜和杂质水杨酸铜的含量；阿司匹林铜，水杨酸铜的检出限分别为０．８７ｍｇ／Ｌ，２．４６ｍｇ／Ｌ；阿司匹林铜的回收率为９９．０％－１００．５０％；水杨酸铜的回收率为
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| 关 键 词： | 阿司匹林铜 高效液相色谱 |
Determination of Copper Aspirinate by High Performance Liquid Chromatography |
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| Liu Zhudong,Liu Weiping,Yang Yikun,Pu Shaoping,Chen Xizhu,He Jian,Xiong Huizhou.Determination of Copper Aspirinate by High Performance Liquid Chromatography[J].Chinese Journal of Analytical Chemistry,1999,27(10):1160-1163. |
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| Authors: | Liu Zhudong Liu Weiping Yang Yikun Pu Shaoping Chen Xizhu He Jian Xiong Huizhou |
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| Abstract: | A method for determining copper aspirinate Cu( ASA)2 ]2 has been studied by using reversed-phase high performance liquid chromatography with YWQ C18 column, MeOH:H2O (containing 0.08% H3PO4):CH3COCH3(11 .4:8.6:1.1) as mobile phase and UV-235 nm as detector. The results showed that Cu(ASA)2]2 and copper salicylate Cu(SA)2]2 could separated satisfactorily. The detection limits of Cu(ASA)2]2 and Cu(SA)2]2 were 0.87 mg/L, 2.46 mg/L respectively and the corresponding recoveries were 99.0%-100.5% . |
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| Keywords: | Copper aspilinate high performance liquid chromatography |
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