"O-acyl isopeptide method" for peptide synthesis: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH |
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| Authors: | Yoshiya Taku Taniguchi Atsuhiko Sohma Youhei Fukao Fukue Nakamura Setsuko Abe Naoko Ito Nui Skwarczynski Mariusz Kimura Tooru Hayashi Yoshio Kiso Yoshiaki |
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| Institution: | Department of Medicinal Chemistry, Center for frontier Research in Medicinal Science, 21st Century COE program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan. |
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| Abstract: | The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH (1-40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method. |
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