Diastereotopos-differentiating C-H activation reactions at methylene groups

The activation of C-H bonds has become a widely used method which allows for the direct transformation of C-H bonds into synthetically more valuable C-C and C-X bonds in a selective manner. This critical review aims to summarize and to highlight a specific subgroup of these transformations, C-H activation reactions of chiral substrates bearing diastereotopic hydrogen atoms at methylene groups (95 references).