Application of the copper catalysed N-arylation of amidines in the synthesis of analogues of the chemical tool, blebbistatin |
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| Authors: | Lawson Christopher P A T Slawin Alexandra M Z Westwood Nicholas J |
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| Institution: | School of Chemistry and the Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, Scotland KY16 9ST, UK. |
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| Abstract: | A robust protocol for the CuI-catalysed arylation of amidines is presented. Whilst the initially identified conditions were useful for benzamidine-derived substrates, difficulties were encountered with more complex substrates. This problem was overcome following a change in ligand type, enabling the synthesis of analogues of the chemical tool, blebbistatin. |
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