Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans |
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Authors: | Di Micco Simone Mazué Frédéric Daquino Carmelo Spatafora Carmela Delmas Dominique Latruffe Norbert Tringali Corrado Riccio Raffaele Bifulco Giuseppe |
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Affiliation: | Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084, Fisciano (SA), Italy. |
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Abstract: | The biological properties and possible pharmacological applications of benzo[kl]xanthene lignans, rare among natural products and synthetic compounds, are almost unexplored. In the present contribution, the possible interaction of six synthetic benzo[kl]xanthene lignans and the natural metabolite rufescidride with DNA has been investigated through a combined STD-NMR and molecular docking approach, paralleled by in vitro biological assays on their antiproliferative activity towards two different cancer cell lines: SW 480 and HepG2. Our data suggest that the benzo[kl]xanthene lignans are suitable lead compounds for the design of DNA selective ligands with potential antitumour properties. |
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