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Synthesis of alkyl 4-aryl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates |
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| Authors: | V L Gein M I Kazantseva L F Gein P A Slepukhin |
| Institution: | 1. Perm’ State Pharmaceutical Academy, Perm, 614990, Russia 2. Vagner Perm’ State Medical Academy, Perm, Russia 3. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia |
| Abstract: | Reactions of alkyl acetoacetates, aromatic aldehydes, ammonium acetate, and 1,3-cyclohexanedione afford alkyl 4-aryl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates. The structure of compounds obtained was established with the help of IR, 1H NMR, and mass spectra and by X-ray diffraction analysis. |
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