Thermal response of superparamagnetic particles suspended in liquid and solid media |
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| Authors: | Pengyun Zeng Jian-ping Wang |
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| Affiliation: | a Department of Pharmaceutics, University of Minnesota, 308 Harvard Street SE, Minneapolis, MN 55455, USA
b Department of Electrical and Computer Engineering, University of Minnesota, 200 Union Street SE, Minneapolis, MN 55455, USA |
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| Abstract: | The purpose of this study was to explore the properties of coated superparamagnetic nanoparticles (SPNs) specifically for their use in thermal-responsive drug delivery systems. Coated, magnetite SPNs were prepared and dispersed in cyclohexane or cetyl alcohol, a solid lipid at the physiological temperatures of 37 °C. The induced temperature change as a function of SPN concentration and external magnetic field and frequency was consistent with theoretical predictions. SPNs dispersed in a solid lipid matrix underwent heating and the associated melting occurred at a temperature suitable for a thermal-responsive drug delivery system. |
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| Keywords: | 75.75.+a |
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