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| 三溴异氰脲酸和DABCI-Br作为高效催化剂用于羟基硅烷化 | |
| 作者单位： | Department of Chemistry，Faculty of Sciences，Persian Gulf University，Bushehr 75169，Iran，Faculty of Chemistry，Bu-Ali Sina University，P.O.Box 4135，Hamedan 6517838683，Iran，School of Pharmacy，Hamedan University of Medical Sciences，65178 Hamedan，Iran，Faculty of Chemistry，Bu-Ali Sina University，P.O.Box 4135，Hamedan 6517838683，Iran |
| 摘 要： | The protection and deprotection of functionalgroups are indispensable in the synthesis of polyfunc-tional compounds.In addition,several chemical con-versions and multiple sequence syntheses are often re-quired for the protection of hydroxyl groups.Thesily… |
| 关 键 词： | DABCO-溴 催化剂 催化作用 化学分析 |
Tribromoisocyanuric Acid and DABCO-Br as Efficient Catalysts for the Silylation of Hydroxyl Groups with Hexamethyldisilazane |
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| Authors: | Khodabakhsh NIKNAM Mohammad Ali ZOLFIGOL Gholamabbas CHEHARDOLI Mina DEHGHANIAN |
| Institution: | 1. Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran 2. Faculty of Chemistry, Bu-Ali Sina University, P.O. Box 4135, Hamedan 6517838683, Iran 3. School of Pharmacy, Hamedan University of Medical Sciences, 65178 Hamedan, Iran |
| Abstract: | Many primary, secondary, tertiary alcohols, and phenolic hydroxyl groups were effectively converted to their corresponding trimethylsilyl ethers using hexamethyldisilazane in the presence of catalytic amounts of tribromoisocyanuric acid and DABCO-bromine under mild conditions at room temperature with short reaction times in good to excellent yields. Excellent chemoselective silylation of hydroxyl groups in the presence of other functional groups were also observed. |
| Keywords: | tribromoisocyanuric acid DABCO-bromine hexamethyldisilazane silylation hydroxyl group |
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