Effect of temperature on triazole and bistriazole formation through copper-catalyzed alkyne-azide cycloaddition |
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Authors: | Jaime GonzálezVíctor M Pérez David O JiménezGermán Lopez-Valdez David CoronaErick Cuevas-Yañez |
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Institution: | Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Carretera Toluca-Atlacomulco Km. 14.5, Toluca, Estado de México 52000, Mexico |
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Abstract: | Temperature is an important factor in the copper catalyzed alkyne azide cycloaddition under oxidative conditions. 1,2,3-Triazoles were obtained in high yields when several alkynes and azides were reacted at methanol reflux using catalytic amounts of both copper iodide and sodium hydroxide. On the other hand, bistriazoles were major products when reactions were performed at −35 °C using excess sodium hydroxide. |
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