Assembly of an unprecedented metal-pipemidic acid complex modifying octamolybdates containing like DNA spiral chain |
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| Institution: | 1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China;2. Department of Material and Chemical Engineering, Chizhou University, Chizhou, Anhui 247000, PR China;1. Key Laboratory of Theoretical Organic Chemistry and Functional Molecule for Ministry of Education, Hunan University of Science and Technology, Xiangtan 411201, China;2. Jiangmen Youju New Materials Co., Ltd, Jiangmen 529000, China;3. Lachman Institute for Pharmaceutical Analysis, Long Island University-Brooklyn Campus, Brooklyn, NY 11201, USA;4. Southern University of Science and Technology, Shenzhen 518000, China;1. College of Chemical Engineering, Hebei United University, 46 West Xinhua Road, Tangshan 063009, Hebei, PR China;2. Department of Inorganic and Physical Chemistry, Ghent University, Krijgslaan 281 S3, B-9000 Ghent, Belgium;1. Laboratoire de Matériaux, Cristallochimie et de Thermodynamique Appliquée, Université de Monastir, Faculté des Sciences Monastir, 5000, Monastir, Tunisia;2. EaStCHEM, School of Chemistry, University of St Andrews, St Andrews, Fife, KY16 9ST, Scotland, UK |
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| Abstract: | By introducing antibacterial drugs pipemidic acid into the octamolybdates, an unprecedented compound, Zn(PPA)2(H2O)]2·Mo8O26]·3.5H2O (1) (PPA = pipemidic acid), has been synthesized and characterized by routine physical methods. Single-crystal X-ray diffraction analysis reveals that the title compound contains the right- and left-double-stranded like DNA helical chains, which are assembled together via sharing the β-Mo8 clusters forming the fascinating double intertwined inverted helices. The result of the antitumor activities shows that the title compound possesses higher antitumor activity and selectivity. |
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| Keywords: | Polyoxometalates Octamolybdates Pipemidic acid DNA Antitumor activity |
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