Modified MCM-41 as a drug delivery system for acetylsalicylic acid |
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| Institution: | 1. Department of Chemistry, Oakland University, Rochester, MI 48309-4401, United States;2. Departmentof Physics, Oakland University, Rochester, MI 48309-4401, United States;3. Department of Materials Science and Engineering, Hubei University, Wuhan 430062, China;4. Departmentof Electrical and Computer Engineering, Oakland University, Rochester, MI 48309-4401, United States;1. CRNN, University of Calcutta, Kolkata 700098, India;2. S.N. Bose National Centre for Basic Science, Kolkata 700098, India;1. Department of Physics, Andhra University, Visakhapatnam 530 003, India;2. Department of Engineering Physics, Andhra University, Visakhapatnam 530 003, India;3. IICT, Hyderabad, India;1. School of Information Science and Technology, Yunnan Normal University, Kunming 650500, China;2. Department of Chemical Engineering, New York International University of Technology and Management, NY, USA;3. Department of Chemistry, Faculty of Science, Ardabil Branch, Islamic Azad University, Ardabil, Iran;4. Department of Chemistry, Faculty of Science, University of Jiroft, Jiroft, Iran;5. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 67149-67346, Iran;1. Dpt. of Analytical Chemistry, University of the Basque Country, P.O. Box 644, E-48080 Bilbao, Spain;2. Dpt. of Stratigraphy and Paleontology, University of the Basque Country, P.O. Box 644, E-48080 Bilbao, Spain |
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| Abstract: | The modification of prepared MCM-41 by different groups (amino, chloro and oxo) was studied. Prepared materials were treated by acetylsalicylic acid and hybrid materials were characterized, compared from the point of view of immobilized amount of active substance. The highest amount of acetylsalicylic acid was detected using methyl-tert- butyl ether as a solvent and MCM-41 without modification after 1 h (0.35 g per 1 g of the support) or MCM modified by amino group after 5 h (0.37 g per 1 g of the support) as a support. Using amino modified MCM, the longer treatment by acetylsalicylic acid converged to the equilibrium and after 24 h the immobilized amount was 0.3 g per 1 g. A dissolution in vitro study was carried out, comparing the stability of formed interactions. The slowest dissolution was detected using non-modified MCM-41 and oxo modified material. |
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| Keywords: | Acetylsalicylic acid MCM-41 Surface modification Dissolution |
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