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Voltammetric determination of uric acid in the presence of ascorbic acid and dopamine using chitosan/ionic liquid composite electrode |
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| Authors: | Yonghong Li Xiurong Zhai Xinsheng Liu Xiaoling Ji Ling Wang |
| Institution: | 1. School of Public Health, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China 2. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People’s Republic of China 3. Department of Chemistry and Chemical Engineering, Jining University, Qufu, 273155, People’s Republic of China 4. Higher Vocational Technical School, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China |
| Abstract: | A chitosan/ionic liquid composite electrode was prepared and used to determine uric acid (UA) in the presence of a large excess of ascorbic acid (AA) and dopamine (DA) by linear sweep voltammetry (LSV). The modified electrode shows large peak separations between DA, AA, and UA. Due to the existence of chitosan and ionic liquid in the composite, the modified electrode exhibits strong electrochemical catalytic activity toward the oxidation of UA. Under optimal conditions, the peak current is linearly dependent on the UA concentration in the range of 5?×?10?7–2?×?10?4 M in the presence of 5?×?10?4 M AA and 5?×?10?5 M DA with a correlation coefficient of 0.9978, and the detection limit is 5?×?10?8 M at a signal-to-noise ratio of 3. With good sensitivity and stability, the constructed sensor was applied in the determination of UA in human serum samples and satisfactory results were obtained. |
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