Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones |
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| Authors: | Bandini Marco Sinisi Riccardo Umani-Ronchi Achille |
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| Institution: | Dipartimento di Chimica G. Ciamician, Università di Bologna, Via Selmi 2, 40126, Bologna, Italy. marco.bandini@unibo.it |
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| Abstract: | Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereoinduction (ee 76-99%) under mild reaction conditions and low loading of catalyst (1-5 mol%). |
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