Organosilicon compounds III. Silicon-substituted thiophene derivatives of mercaptoethylamine as possible radioprotective agents |
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Authors: | Shelby F Thames Josef E Mccleskey |
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Abstract: | The preparation of the first organosilicon containing derivatives of mercaptoethylamine as possible radioprotective agents is described. The synthesis of these compounds via the thiazolidine intermediate was chosen due to the known radioprotective action of certain thiazolidines. We have prepared seventeen previously unreported organosilicon derivatives of which eleven contain the thiazolidine moiety and six are derivatives of mercaptoethylamine. The ability of these derivatives to protect against ionizing radiation will be determined. |
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