自由基引发的可注射PLA-b-PEG-b-PLA大分子单体和α-CD超分子结构水凝胶的合成与表征

以数均分子量为6000的聚乙二醇为引发剂,以辛酸亚锡为催化剂引发丙交酯开环,再用甲基丙烯酸酐进行封端生成大分子单体.然后将大分子单体和α-环糊精混合,分别用维生素C和硫酸亚铁与过硫酸铵组成的氧化还原引发剂引发聚合,得到了两种不同结构的超分子结构水凝胶.用1HNMR,FTIR,TGA和XRD等分析测试手段对大分子单体及形成的水凝胶进行了表征.流变仪测试结果表明,该水凝胶固化时间合适,并具有可注射性.

Synthesis and Characterization of Injectable Supramolecular Structured Hydrogels Prepared by Free Radical Polymerization of PLA-b-PEG-b-PLA Macromers and α-Cyclodextrins

Poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) triblock copolymer(PLA-PEG-PLA) was synthesized by the ring-opening polymerization of L-lactide with poly(ethylene glycol)(PEG6000) as the initiator and Sn(Oct)-2 as the catalyst in toluene.This copolymer was further reacted with methacrylic anhydride to give a soluble macromer terminated with methacryloyl groups.Two kinds of supramolecular structured hydrogels were obtained through mixing the macromer with α-cyclodextrins and then initiating by using ammonium persulphate with ascorbic acid or ferrous sulfate.The macromer and hydrogels were characterized by 1H NMR,FTIR,TGA and XRD etc..Based on rheological test,the two kinds of the resultant hydrogels are injectable with appropriate pot-life.