Bioaccumulation and biotransformation of flavonols by erythrocytes |
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| Authors: | E V Bondaryuk V V Senchuk |
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| Institution: | (1) Belorussian State University, Republic of Belarus, Minsk, 220030, prosp. Nezavisimosti, 4, Belarus |
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| Abstract: | A model for the complete system of bioaccumulation, transport, and biotransformation of polyphenolic compounds (flavonols)
that includes hemoglobin-containing red blood cells and serum albumin was proposed. The distribution of flavonols between
the erythrocyte fraction and albumin was studied. Hemoglobin was shown to play a role in the biotransformation of flavonols.
The formation of several intermediate and final products of pseudoperoxidase oxidation of flavonols catalyzed by methemoglobin
was established by UV spectrophotometry and RP-HPLC.
Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 153-157, March-April, 2009. |
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| Keywords: | flavonols quercetin fisetin morin rutin hemoglobin serum albumin erythrocytes pseudoperoxidase oxidation |
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