Synthesis, crystal structure and in vitro antitumor activity of a novel organotin(IV) complex with 9-hexyl-9H-carbazole-3-carboxylic acid |
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| Authors: | Y. K. Liang B. F. Ruan Y. P. Tian |
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| Affiliation: | 1. Department of Chemistry, Anhui University, and Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Hefei, 230039, P.R. China
2. School of Medical Engineering, Hefei University of Technology, Hefei, 230009, P.R. China
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| Abstract: | 9-Hexyl-9H-carbazole-3-carboxylic acid (LCOOH) and its complex with Ph3Sn(OH), [Ph3SnO2CL] (I), were synthesized. The structure of complex I was solved by single-crystal X-ray diffraction determination, indicating that I shows the discrete framework. Furthermore, this complex was tested in vitro for its cytotoxic activity, using human hepatocellular carcinoma cell line (BEL-7402) and human hepatocellular liver carcinoma cell line (HepG2); 5-fluorouracil was used as a positive control substance. This complex showed cytotoxicity greater than that of 5-fluorouracil. |
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