Synthesis of acetals containing a primary amino group |
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| Authors: | N. A. Lobanova V. K. Stankevich B. F. Kukharev |
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| Affiliation: | 1. Favorskii Irkutsk Institute of Chemistry, Siberian Division, Russian Academy of Sciences, ul. Favorskogo 1, Irkutsk, 664033, Russia
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| Abstract: | Amino acetals of the general formula MeCH(OR)(OXNH2) (R = Et, Bu, X = CH2CH2, CH2CH2CH2, CH2CMe2) were synthesized in 53?C91% yield by acid-catalyzed reaction of N-(2-hydroxyethyl)-, N-(3-hydroxypropyl)-, and N-(2-hydroxy-1,1-dimethylethyl)-2,2,2-trifluoroacetamides with vinyl ethers, followed by removal of the trifluoroacetyl protection by alkaline hydrolysis. |
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