Study of regioselectivity of reactions between 3(5)-aminopyrazoles and 2-acetylcycloalkanones |
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Authors: | A A Petrov A N Kasatochkin E E Emelina |
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Institution: | 1. St. Petersburg State University, St. Petersburg, 198504, Russia
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Abstract: | Regioselectivity was examined of reactions between nine 3(5)-aminopyrazoles and 2-acetylcyclopentanone and 2-acetylcyclohexanone under various conditions. A series of cyclopentae]pyrazolo-1,5-a]pyrimidines was obtained. The highest regioselectivity of the reaction was observed in alcohol at 20°C in the presence of a catalytic quantity of trifl uoroacetic acid. The regiostructure of compounds was established by 1H and 13C NMR spectroscopy. |
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