| DL-苯丙氨酸-1-14C化学合成及酶促拆分 |
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| 引用本文： | 严兆明,冯冬梅,陈耀焕,盛怀禹. DL-苯丙氨酸-1-14C化学合成及酶促拆分[J]. 有机化学, 1987, 7(3): 216-218 |
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| 作者姓名： | 严兆明 冯冬梅 陈耀焕 盛怀禹 |
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| 作者单位： | 中国科学院上海有机化学研究所 上海 |
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| 摘 要： | 本文报道 DL-苯丙氨酸-1-(14)~C 的合成,并利用嗜热菌蛋白酶酶促拆分光学异构体。化学产率和放化产率一致,可达67%,标记化合物的放化纯度高于95%。
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| 关 键 词： | 二肽 碳14 苯丙氨酸 嗜热菌蛋白酶 酶促 消旋体拆分 |
SYNTHESIS OF DL-PHENYLALANINE-1-~(14)C AND ITS ENZYMATIC RESOLUTION |
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| Yan Zhaoming Feng Dongmei Chen Yaohuan Sheng Huaiyu. SYNTHESIS OF DL-PHENYLALANINE-1-~(14)C AND ITS ENZYMATIC RESOLUTION[J]. Chinese Journal of Organic Chemistry, 1987, 7(3): 216-218 |
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| Authors: | Yan Zhaoming Feng Dongmei Chen Yaohuan Sheng Huaiyu |
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| Affiliation: | Yan Zhaoming~* Feng Dongmei Chen Yaohuan Sheng Huaiyu |
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| Abstract: | DL-phenylalanine-1-~(14)C was synthesized by Strecker method and resolv-ed to optical isomers by enzymatic reaction with thermolysin.Both the overall chem-ical and radioactive yields were found to be consistent with each other(67%) andthe radioactive purity of labelled compound was over 95%. |
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| Keywords: | dipeptide carbon 14 phenylalanine thermolysin enzymatic resolution |
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