Endoscopic, rapid near-infrared optical tomography |
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Authors: | Piao Daqing Xie Hao Zhang Weili Krasinski Jerzy S Zhang Guolong Dehghani Hamid Pogue Brian W |
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Affiliation: | School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, Oklahoma, USA. daqing.piao@okstate.edu |
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Abstract: | This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source-detector fibers for tomography as well as parallel sampling of all source-detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation. |
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