Assignment of absolute configuration to SCH 351448 via total synthesis |
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Authors: | Cheung Lael L Marumoto Shinji Anderson Christopher D Rychnovsky Scott D |
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Affiliation: | Department of Chemistry, University of California, Irvine, California 92697-2025, USA. |
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Abstract: | The synthesis and absolute configuration of SCH 351448, an interesting ionophoric natural product, are reported herein. Mukaiyama aldol-Prins and segment-coupling Prins reactions were employed to construct the constituent tetrahydropyrans of SCH 351448. Efforts to assemble the C2-symmetric core of the natural product by a templated olefin metathesis strategy are described; however, a stepwise fragment assembly was ultimately utilized to complete the target molecule. |
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