| Synthesis and bioactivity of N-tert-butyl-N′-acyl-5-methy 1-1,2,3-thiadiazole-4-carbohydrazides |
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| 作者姓名： | Tatiana Kalinina Yu.Morzherin Yury A.Bakulev Vasiliy |
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| 作者单位： | Department of Chemistry, Tianjin University, Tianjin 300072, China ; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China ; The Ural Federal University Named after the First President of Russia B.N. Yeltsin, Yeltsin UrFU 620002, Ekaterinburg, Russia |
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| 基金项目： | funded in part by the NNSFC(No.20872071);the NSF of Tianjin(No.10JCZDJC17500);the National Key Project for Basic Research(No.2010CB126105);National Key Technology Research and Development Program(Nos.2011BAE06B02 and 2011BAE06B05);the Foundation of Achievements Transformation and Application of Tianjin Agricultural Science and Technology(No.201002250);Tianjin Key Technology Research and Development Program(No.11ZCGYNC00100) |
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| 摘 要： | A series of novel N-tert-butyl-N′-acyl-5-memyl-l,2,3-thiadiazole-4-carbohydrazides were designed and synthesized.Their structures were characterized by melting points,~1H NMR,IR,ESI-MS,and elemental analysis.The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in vivo at 50μg/mL,which was better than that of Ninamycin and tiadinial.Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development.
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| 关 键 词： | Antivirus activity Systemic acquired resistance Synthesis 1,2,3-Thiadiazole Diacylhydrazine |
| 收稿时间： | 2012-08-02 |
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