An efficient total synthesis of (+/-)-lycoramine |
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| Authors: | Fan Chun-An Tu Yong-Qiang Song Zhen-Lei Zhang En Shi Lei Wang Min Wang Baomin Zhang Shu-Yu |
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| Institution: | State Key Laboratory of Applied Organic Chemistry & Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China. |
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| Abstract: | reaction: see text] A short and unique approach to (+/-)-lycoramine as one of the galanthamine-type alkaloids has been efficiently developed. The alternative advantage lies in that three stereocenters, including a crucial quaternary carbon center, were constructed with high diasteroselectivity via a key one-step NBS-mediated semipinacol rearrangement of the allylic alcohol. |
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