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A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer |
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| Authors: | Freire Felix Cuesta Igor Corzana Francisco Revuelta Julia González Carlos Hricovini Milos Bastida Agatha Jiménez-Barbero Jesús Asensio Juan Luis |
| Affiliation: | Instituto de Química Orgánica General (CSIC), c/Juan de la Cierva 3, Madrid, Spain. |
| Abstract: | A complete characterisation of the protonation equilibrium that accompanies the molecular recognition of neomycin-B by a specific RNA receptor has been achieved by employing simple NMR measurements. |
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