BIOLOGICAL ACTIVITIES OF PHTHALOCYANINES-XL PHOTOTOXICITY OF SULFONATED ALUMINUM NAPHTHALOCYANINES TOWARDS V-79 CHINESE HAMSTER CELLS |
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| Authors: | Benoit Paquette Hasrat Ali Rejean Langlois Johan E van Lier |
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| Institution: | MRC Group in the Radiation Sciences, Faculty of Medicine, University of Sherbrooke, Quebec, Canada. |
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| Abstract: | The phototoxicity of sulfonated aluminum naphthalocyanines towards V-79 Chinese hamster cells is investigated. The disulfonated naphthalocyanine exhibits similar photostability, but better cell penetrating properties than the tetrasulfonated dyes. The capacity of the naphthalocyanines to generate singlet oxygen is comparable to that of the corresponding phthalocyanines. However, in contrast to the phthalocyanine dyes, the sulfonated aluminum naphthalocyanines show very little phototoxicity towards the V-79 cells, suggesting close association with non-vital cell constituents or extensive formation of photoinactive adducts and aggregates. |
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