|
|||||
|
|
Determining the absolute configuration of secondary alcohols by means of a chiral auxiliary and NOESY |
|
| Authors: | Blanca E Domínguez Patricia E García Jorge Crdenas |
| Institution: | aCentro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62210 Cuernavaca, Morelos, Mexico bInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, D.F., Mexico |
| Abstract: | The absolute configuration of secondary alcohols can be determined by NOE between the diastereotopic protons of the lactam and the protons of the alcohol moieties in some 1-(alkoxymethyl)-methyl-2-pyrrolidone-5-carboxylate derivatives. Two simple methods based on conformational analysis and 1H NMR data have been developed. The main conformer, in all cases, was established by means of MM, semi-empirical, and ab initio calculations. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |